Hot Melt Extrusion
Hot melt extrusion at Losan Pharma
The Hot Melt Extrusion technology can be used in the formulation development of low soluble drug substances to significantly enhance the solubility of these compounds in a continuous process.
Losan´s HME technology is leading to:
- an increase of the in-vivo absorption (AUC, Cmax)
- immediate or sustained release dosage forms
- a taste masking of APIs
Fast screening including a DoE, a pilot scale and production scale is available for all stages of clinical development and commercialisation.
The Hot melt extrusion process has been used since 1930 in plastics industry. Extrusion can be simply defined as the process of forming a new material (the extrudate) by forcing it through an orifice or die under controlled conditions, such as temperature, mixing, feed-rate and pressure. An HME technique is utilised in the formulation development of poorly water solubles because of the enhanced dissolution properties, absorption and therapeutic efficacy.